From Nature Clinical Practice Gastroenterology & Hepatology
Dietary Treatment for Obesity
by Peter M Clifton
Summary
In patients with obesity, low-fat diets seem to result in a weight loss of 3–4 kg at 3 years, but long-term data are limited.
Calorie-controlled diets seem to outperform low-fat diets with reported weight losses of 6–7 kg at 4 years, but, again, data are very limited; an initial very-low-calorie diet approach does not lead to greater weight loss than low-fat diets in the long term.
Use of meal replacements can lead to an 8 kg weight loss at 4 years, but this finding has been reported only in one, uncontrolled study.
High-protein, low-carbohydrate (or very-low-carbohydrate) diets have also been evaluated and seem to be superior to high-carbohydrate diets at least for up to 2 years.
Very-low-carbohydrate diets can lead to elevations in LDL cholesterol levels in some individuals.
Cognitive behavioral therapy added to diet therapy can facilitate approximately 5 kg additional weight loss, and exercise can facilitate an additional 1–1.5 kg weight loss.
Drug treatment, particularly with sibutramine and rimonabant, can increase weight loss with a mildly hypocaloric diet by an additional 3–5 kg, but weight-loss drugs are costly and have adverse effects.
If dietary and medical therapies fail, gastric banding can lead to a weight loss of ~14% at 10 years, with greater losses of up to 25% with gastric bypass and gastroplasty.
Bariatric surgery can also lead to a reduction in mortality and comorbidities but adverse effects can occur including nutritional deficiencies and gastrointestinal symptoms.
http://www.medscape.com/viewarticle/585033?src=sr
Wednesday, January 14, 2009
Monday, January 12, 2009
Benefits of Probiotics Reviewed
Am Fam Physician. 2008;78:1073-1078.
Probiotics are live microorganisms that are ingested in amounts sufficient to benefit the health of the host. Although probiotics may be widely used for a variety of conditions, available evidence supports their use only for a small number of conditions.
Probiotics may have several mechanisms of action underlying their benefits. In preventing and treating gastrointestinal tract infection, probiotics may be helpful because of direct competition between pathogenic bacteria in the gut and immune modulation and enhancement. Probiotics may affect early development of immune tolerance during the first year of life, explaining their potential effect in children with atopic dermatitis.
Study Highlights
Probiotics used most widely and tested most rigorously include Lactobacillus species, Bifidobacterium species, and the nonpathogenic yeast S boulardii,
Probiotics are considered to be safe and effective for the prevention and treatment of antibiotic-associated diarrhea and infectious diarrhea.
Good evidence indicates that probiotics, especially S boulardii and L rhamnosus GG, help prevent antibiotic-related diarrhea.
Good evidence indicates that probiotic treatment of all-cause infectious diarrhea decreases both the duration of illness and the severity of symptoms.
Small studies suggest that in patients with irritable bowel syndrome, probiotic therapy may decrease the severity of pain and abdominal bloating.
Probiotics may help prevent atopic dermatitis in at-risk infants, and some preliminary evidence suggests that symptoms of atopic dermatitis may also respond to probiotic therapy.
Probiotics are sometimes used for vaginal candidiasis, stomach infection with H pylori, inflammatory bowel disease, and upper respiratory tract infections, but evidence is lacking to support these indications.
Frequently used dosages range from 5 to 10 billion colony-forming units per day for children and from 10 to 20 billion colony-forming units per day for adults, depending on the specific microorganism or combination used.
The dosages of S boulardii used in most studies range from 250 to 500 mg/day.
Common adverse effects of probiotics are mild and self-limited, including flatulence and mild abdominal discomfort.
Septicemia and other severe adverse effects of probiotics are rare.
Probiotics should be used only with caution in patients with short-gut syndrome. They should not be given to patients with conditions that severely compromise the immune system.
Available formulations of probiotics include capsules, powder, tablets, liquid, or incorporated into food. These may vary in quality and biological activity and should be obtained from a reliable supplier.
Pearls for Practice
On the basis of good evidence, probiotics are considered to be safe and effective for the prevention and treatment of antibiotic-associated diarrhea and infectious diarrhea. For prevention of antibiotic-related diarrhea, available evidence favors S boulardii and L rhamnosus GG. Probiotic treatment of all-cause infectious diarrhea decreases both the duration of illness and the severity of symptoms.
Small studies suggest that in patients with irritable bowel syndrome, probiotic therapy may decrease the severity of pain and abdominal bloating. Probiotics may help prevent atopic dermatitis in at-risk infants, and some preliminary evidence suggests that symptoms of atopic dermatitis may also respond to probiotic therapy
Probiotics are live microorganisms that are ingested in amounts sufficient to benefit the health of the host. Although probiotics may be widely used for a variety of conditions, available evidence supports their use only for a small number of conditions.
Probiotics may have several mechanisms of action underlying their benefits. In preventing and treating gastrointestinal tract infection, probiotics may be helpful because of direct competition between pathogenic bacteria in the gut and immune modulation and enhancement. Probiotics may affect early development of immune tolerance during the first year of life, explaining their potential effect in children with atopic dermatitis.
Study Highlights
Probiotics used most widely and tested most rigorously include Lactobacillus species, Bifidobacterium species, and the nonpathogenic yeast S boulardii,
Probiotics are considered to be safe and effective for the prevention and treatment of antibiotic-associated diarrhea and infectious diarrhea.
Good evidence indicates that probiotics, especially S boulardii and L rhamnosus GG, help prevent antibiotic-related diarrhea.
Good evidence indicates that probiotic treatment of all-cause infectious diarrhea decreases both the duration of illness and the severity of symptoms.
Small studies suggest that in patients with irritable bowel syndrome, probiotic therapy may decrease the severity of pain and abdominal bloating.
Probiotics may help prevent atopic dermatitis in at-risk infants, and some preliminary evidence suggests that symptoms of atopic dermatitis may also respond to probiotic therapy.
Probiotics are sometimes used for vaginal candidiasis, stomach infection with H pylori, inflammatory bowel disease, and upper respiratory tract infections, but evidence is lacking to support these indications.
Frequently used dosages range from 5 to 10 billion colony-forming units per day for children and from 10 to 20 billion colony-forming units per day for adults, depending on the specific microorganism or combination used.
The dosages of S boulardii used in most studies range from 250 to 500 mg/day.
Common adverse effects of probiotics are mild and self-limited, including flatulence and mild abdominal discomfort.
Septicemia and other severe adverse effects of probiotics are rare.
Probiotics should be used only with caution in patients with short-gut syndrome. They should not be given to patients with conditions that severely compromise the immune system.
Available formulations of probiotics include capsules, powder, tablets, liquid, or incorporated into food. These may vary in quality and biological activity and should be obtained from a reliable supplier.
Pearls for Practice
On the basis of good evidence, probiotics are considered to be safe and effective for the prevention and treatment of antibiotic-associated diarrhea and infectious diarrhea. For prevention of antibiotic-related diarrhea, available evidence favors S boulardii and L rhamnosus GG. Probiotic treatment of all-cause infectious diarrhea decreases both the duration of illness and the severity of symptoms.
Small studies suggest that in patients with irritable bowel syndrome, probiotic therapy may decrease the severity of pain and abdominal bloating. Probiotics may help prevent atopic dermatitis in at-risk infants, and some preliminary evidence suggests that symptoms of atopic dermatitis may also respond to probiotic therapy
Friday, January 9, 2009
Update on Treatment for Chronic Pain
Selection from:
Highlights of the American Academy of Pain Management 19th Annual Clinical Meeting
An Update on Chronic Pain Treatments CME/CE
Andrew N. Wilner, MD, FAAN, FACP
At the 2008 American Academy of Pain Management (AAPM) meeting in Nashville, Tennessee, experts addressed 3 problematic areas of chronic pain: chronic pelvic pain in women, headache, and fibromyalgia.
In order to treat the common problem of chronic pelvic pain in women, clinicians must focus on identifying one of the multiple causes, as many women will respond to therapy. When no cause is found, empiric treatment for unseen endometriosis may be successful.
For patients with chronic headache, the differential diagnosis is wide but severe underlying causes are rare, with most patients suffering from migraine, chronic daily headache, or cluster headache. Because of comorbidities such as bipolar and personality disorder, variability of response to medications, and other factors, algorithms are of limited usefulness and treatment must be individualized.
Fibromyalgia is a disease of multifactorial origin that is still not accepted as a "real disease" by many clinicians but can be diagnosed by specific criteria from the American College of Rheumatology (ACR). The identification and treatment of comorbidities may be even more important in fibromyalgia than in patients with migraine. In all patients with chronic pain, providers must be aware of the potential for addiction in their patients and develop safeguards for its prevention.
Chronic Pelvic Pain
Ayman Al-Hendy, MD, PhD, Director of the Center for Women's Health Research, Meharry Medical College, Nashville, Tennessee, explained that identifying and treating chronic pelvic pain represents a challenge for women's health and primary care practitioners. Up to 15% of women have chronic pelvic pain, but 75% do not consult a healthcare provider and only 10% consult a gynecologist. Chronic pelvic pain may result from a wide spectrum of disorders, including gastrointestinal, gynecologic, musculoskeletal, psychiatric, rheumatologic, and urologic.
In a laparoscopy study of 1318 women with chronic pelvic pain, the most common gynecologic cause for chronic pelvic pain was endometriosis (28%), followed by adhesions (25%) and chronic pelvic infection (6%). Less common causes included ovarian cysts, leiomyomas, pelvic varicosities, and "other." No pathology was identified in 39%, but Dr. Al-Hendy suggested that some of these patients may have had undetected endometriosis.
"Pelvic pain with a negative work-up is usually due to endometriosis when you exclude other causes of pain," advised Dr. Al-Hendy.
Evaluation of chronic pelvic pain begins with a detailed history and physical examination and may require laboratory work, imaging studies and procedures such as laparoscopy. Dr. Al-Hendy asks patients to complete a symptom questionnaire in the waiting room prior to the office examination. For successful treatment of patients with nongynecologic causes of chronic pelvic pain, such as fibromyalgia, irritable bowel syndrome, or urethral syndrome, a multidisciplinary pain clinic may be necessary.
On laparoscopy, endometriosis is characterized by a wide variety of lesions, including vesicles, polyps, "windows," diverticulae, adhesions, vascular "red" lesions, and fibrotic "white" lesions. Lesions may also be black, yellow, or clear. The gold standard for the diagnosis is histopathologic evidence of endometrial glands and stroma. Dr. Al-Hendy added that the severity of endometrial disease seen on laparoscopy doesn't correlate well with symptom severity. Further, lesions may remain hidden even from properly performed laparoscopy.
Laparoscopic laser treatment yields significant improvement in 100% of patients with severe endometriosis, 69% of patients with mild disease, and 38% of patients with minimal disease. Dr. Al-Hendy suggested that patients with minimal disease may have lesions hidden from the laparoscope, accounting for the poor treatment response.
The addition of hormonal treatment, a gonadotropin-releasing hormone (GnRH) agonist that induces a "chemical menopause," improves the results of surgical treatment. Even a GnRH agonist without surgery controls symptoms in almost 90% of patients for 1 year, with recurrence of pain symptoms in 50% of patients at 4 years. Dr. Al-Hendy recommended that patients keep a diary of their pain symptoms, which are important to separate from the menopausal symptoms that may result from GnRH therapy, such as headaches, night sweats, and hot flashes.
If there are no visible lesions of endometriosis and the pain does not respond to a GnRH agonist, the cause is probably not endometriosis, concluded Dr. Al-Hendy.
Management of Headache
Lawrence Robbins, MD, Assistant Professor of Neurology at Rush Medical College, Chicago, Illinois, and Director of the Robbins Headache Clinic, Northbrook, Illinois, was the recipient of this year's AAPM Clinical Pain Management Award. In his presentation he reviewed the treatment of chronic headache, with an emphasis on migraine. Other causes of chronic headache include chronic daily headache, cluster headache, and, more rarely, intracranial pathology.
According to Dr. Robbins, migraine affects 28 million people in the United States and is common in all age groups. In addition to head pain, symptoms characteristic of migraine headaches include nausea, photophobia, and relation to the menstrual cycle.
Dr. Robbins explained, "Migraine is like having asthma or diabetes. It's a physical problem."
Patients should be educated about possible migraine triggers. These include relation to the menstrual cycle, undersleeping, stress and daily hassles, weather changes, missing meals, bright lights, and specific foods and drinks. These triggers can be cumulative, resulting in a headache. For example, a weather change occurring on the first day of the menstrual period may trigger a migraine.
Dr. Robbins advised that people with migraine pay attention to their caffeine ingestion. Small amounts of caffeine can help headaches, and 150-200 mg, the amount in a single cup of coffee, is usually enough. However, caffeine tolerance can develop. Some people who miss their routine cups of coffee will develop headaches or depression due to caffeine withdrawal.
Medications are most effective when used early in the headache. There are many choices of triptans, which may be combined with nonsteroidal anti-inflammatory drugs (NSAIDs). Triptans are more effective when used early, before allodynia and sensitization begin. Nontriptan abortive medications include acetaminophen, aspirin, NSAIDs, caffeine, and metoclopramide, as well as dichloralphenazone alone and in combination. Dihydroergotamine (DHE) injections and dihydroergotamine and caffeine nasal spray are also options. Antiemetics include ondansetron and promethazine. Other pain medications include opioids, butalbital, and hydrocodone. Dr. Robbins uses steroids, injectable opioids, butorphanol nasal spray, and fentanyl when the usual abortives do not work. For some patients with intractable headaches, monoamine oxidase inhibitors (MAOIs), stimulants, occipital stimulators, patent foramen ovale surgery, occipital nerve blocks, and cervical injections may be helpful. Dr. Robbins objected to the use of algorithms for the treatment of headache.
"Comorbidities shape how we treat headache patients; anxiety, depression, bipolar spectrum and personality disorders, attention-deficit/hyperactivity disorder, addictions, and insomnia will all influence how we treat the headache," observed Dr. Robbins. "Medical comorbidities that affect the gastrointestinal system, irritable bowel syndrome, constipation, and diarrhea will also influence treatment choice," he added.
"For example, amitriptyline can cause weight gain, constipation, and fatigue, so we wouldn't use it in patients predisposed to these symptoms."
In addition to medical therapies, psychotherapy, biofeedback, exercise, yoga, massage, acupuncture, and other treatments may be useful. "Acceptance is very important, not resignation," advised Dr. Robbins. "However, the patient may have acceptance, but their spouse or family may not, which increases the anxiety and stress of the patient. In addition, active coping is very important compared to passive coping. We want to promote self-efficacy."
Dr. Robbins concluded, "We are not treating headaches, we are treating people and trying to enhance quality of life."
Management of Fibromyalgia
Philip Mease, MD, Chief, Division of Clinical Research, Swedish Hospital Medical Center, Seattle, Washington, described fibromyalgia as a condition characterized by heightened pain sensitivity, fatigue, sleep disturbance, and other symptoms due to dysregulation of neurophysiologic function. Fibromyalgia is not simply a condition that occurs in the developed world; it has a prevalence worldwide ranging from 0.7% (Denmark) to 10.5% (Norway). In the United States, the prevalence of fibromyalgia is 2%.
Fibromyalgia may be diagnosed by applying ACR criteria, which include a history of chronic widespread pain for at least 3 months and identification of at least 11 out of 18 tender points. The ACR diagnostic criteria are 88.4% sensitive and 81.1% specific. Fibromyalgia appears to have a multifactorial pathophysiology, which includes a strong familial predisposition, central pain amplification, psychiatric comorbid conditions, and other factors, such as immune dysregulation and the role of neurohormones such as dopamine, and growth hormone. Magnetic resonance imaging studies have provided objective evidence to show that patients with fibromyalgia have a lower threshold for pain sensitivity.
Multiple comorbid symptoms and syndromes may accompany fibromyalgia, including tension/migraine headache, affective disorders, temporomandibular joint disorder, idiopathic low back pain, irritable bowel syndrome, nondermatomal paresthesias, fatigue, memory and cognitive difficulties, and others. Tension headache is one of the most common comorbidities, occurring in over 70% of women and 50% of men with fibromyalgia.
After confirming a diagnosis, Dr. Mease recommended the identification of important symptom domains, their severity, and level of patient function. The only diagnostic instrument that has been validated for measure of function and quality of life in fibromyalgia is the Fibromyalgia Impact Questionnaire (FIQ). Patients should be evaluated for comorbid medical and psychiatric disorders, psychosocial stressors, level of fitness, and barriers to treatment. Education should be provided about fibromyalgia and treatment options should be reviewed.
Despite different modes of action, a variety of neuromodulatory agents may improve the symptoms of fibromyalgia patients. These include antidepressants, analgesics, anticonvulsants, muscle relaxants, and sedative hypnotic drugs. Only 2 drugs are FDA-approved for the specific treatment of fibromyalgia: pregabalin (Lyrica®) and duloxetine hydrochloride (Cymbalta®). However, many other medications are used off-label for the treatment of fibromyalgia.
Two pivotal phase 3 trials of the investigational drug milnacipran have been completed recently and showed favorable results for the treatment of fibromyalgia. Statistically significant durable pain relief as well as multidimensional symptom improvement lasted at least 1 year. The main adverse event was nausea (36.7%), with other adverse effects similar to those associated with duloxetine. Milnacipran has been approved in Europe and Asia for the treatment of depression.
Nonpharmacologic therapy for fibromyalgia includes aerobic exercise, cognitive-behavioral therapy, patient education, strength training, acupuncture, biofeedback, balneotherapy, and hypnotherapy. Both the patient's pain and comorbid conditions should be treated. Referral to a specialist may be necessary for complex cases.
Conclusions
The treatment of chronic pelvic pain, migraine, and fibromyalgia requires a directed history, physical examination, and laboratory evaluations to rule out other diagnoses and appreciation of multiple comorbidities that may influence the expression of symptoms and guide treatment choice. Multiple treatment modalities are available, which must be individualized for each patient.
This activity is supported by an educational grant from PriCara, Division of Ortho-McNeil-Janssen Pharmaceuticals Inc., administered by Ortho-McNeil Janssen Scientific Affairs, LLC.
Highlights of the American Academy of Pain Management 19th Annual Clinical Meeting
An Update on Chronic Pain Treatments CME/CE
Andrew N. Wilner, MD, FAAN, FACP
At the 2008 American Academy of Pain Management (AAPM) meeting in Nashville, Tennessee, experts addressed 3 problematic areas of chronic pain: chronic pelvic pain in women, headache, and fibromyalgia.
In order to treat the common problem of chronic pelvic pain in women, clinicians must focus on identifying one of the multiple causes, as many women will respond to therapy. When no cause is found, empiric treatment for unseen endometriosis may be successful.
For patients with chronic headache, the differential diagnosis is wide but severe underlying causes are rare, with most patients suffering from migraine, chronic daily headache, or cluster headache. Because of comorbidities such as bipolar and personality disorder, variability of response to medications, and other factors, algorithms are of limited usefulness and treatment must be individualized.
Fibromyalgia is a disease of multifactorial origin that is still not accepted as a "real disease" by many clinicians but can be diagnosed by specific criteria from the American College of Rheumatology (ACR). The identification and treatment of comorbidities may be even more important in fibromyalgia than in patients with migraine. In all patients with chronic pain, providers must be aware of the potential for addiction in their patients and develop safeguards for its prevention.
Chronic Pelvic Pain
Ayman Al-Hendy, MD, PhD, Director of the Center for Women's Health Research, Meharry Medical College, Nashville, Tennessee, explained that identifying and treating chronic pelvic pain represents a challenge for women's health and primary care practitioners. Up to 15% of women have chronic pelvic pain, but 75% do not consult a healthcare provider and only 10% consult a gynecologist. Chronic pelvic pain may result from a wide spectrum of disorders, including gastrointestinal, gynecologic, musculoskeletal, psychiatric, rheumatologic, and urologic.
In a laparoscopy study of 1318 women with chronic pelvic pain, the most common gynecologic cause for chronic pelvic pain was endometriosis (28%), followed by adhesions (25%) and chronic pelvic infection (6%). Less common causes included ovarian cysts, leiomyomas, pelvic varicosities, and "other." No pathology was identified in 39%, but Dr. Al-Hendy suggested that some of these patients may have had undetected endometriosis.
"Pelvic pain with a negative work-up is usually due to endometriosis when you exclude other causes of pain," advised Dr. Al-Hendy.
Evaluation of chronic pelvic pain begins with a detailed history and physical examination and may require laboratory work, imaging studies and procedures such as laparoscopy. Dr. Al-Hendy asks patients to complete a symptom questionnaire in the waiting room prior to the office examination. For successful treatment of patients with nongynecologic causes of chronic pelvic pain, such as fibromyalgia, irritable bowel syndrome, or urethral syndrome, a multidisciplinary pain clinic may be necessary.
On laparoscopy, endometriosis is characterized by a wide variety of lesions, including vesicles, polyps, "windows," diverticulae, adhesions, vascular "red" lesions, and fibrotic "white" lesions. Lesions may also be black, yellow, or clear. The gold standard for the diagnosis is histopathologic evidence of endometrial glands and stroma. Dr. Al-Hendy added that the severity of endometrial disease seen on laparoscopy doesn't correlate well with symptom severity. Further, lesions may remain hidden even from properly performed laparoscopy.
Laparoscopic laser treatment yields significant improvement in 100% of patients with severe endometriosis, 69% of patients with mild disease, and 38% of patients with minimal disease. Dr. Al-Hendy suggested that patients with minimal disease may have lesions hidden from the laparoscope, accounting for the poor treatment response.
The addition of hormonal treatment, a gonadotropin-releasing hormone (GnRH) agonist that induces a "chemical menopause," improves the results of surgical treatment. Even a GnRH agonist without surgery controls symptoms in almost 90% of patients for 1 year, with recurrence of pain symptoms in 50% of patients at 4 years. Dr. Al-Hendy recommended that patients keep a diary of their pain symptoms, which are important to separate from the menopausal symptoms that may result from GnRH therapy, such as headaches, night sweats, and hot flashes.
If there are no visible lesions of endometriosis and the pain does not respond to a GnRH agonist, the cause is probably not endometriosis, concluded Dr. Al-Hendy.
Management of Headache
Lawrence Robbins, MD, Assistant Professor of Neurology at Rush Medical College, Chicago, Illinois, and Director of the Robbins Headache Clinic, Northbrook, Illinois, was the recipient of this year's AAPM Clinical Pain Management Award. In his presentation he reviewed the treatment of chronic headache, with an emphasis on migraine. Other causes of chronic headache include chronic daily headache, cluster headache, and, more rarely, intracranial pathology.
According to Dr. Robbins, migraine affects 28 million people in the United States and is common in all age groups. In addition to head pain, symptoms characteristic of migraine headaches include nausea, photophobia, and relation to the menstrual cycle.
Dr. Robbins explained, "Migraine is like having asthma or diabetes. It's a physical problem."
Patients should be educated about possible migraine triggers. These include relation to the menstrual cycle, undersleeping, stress and daily hassles, weather changes, missing meals, bright lights, and specific foods and drinks. These triggers can be cumulative, resulting in a headache. For example, a weather change occurring on the first day of the menstrual period may trigger a migraine.
Dr. Robbins advised that people with migraine pay attention to their caffeine ingestion. Small amounts of caffeine can help headaches, and 150-200 mg, the amount in a single cup of coffee, is usually enough. However, caffeine tolerance can develop. Some people who miss their routine cups of coffee will develop headaches or depression due to caffeine withdrawal.
Medications are most effective when used early in the headache. There are many choices of triptans, which may be combined with nonsteroidal anti-inflammatory drugs (NSAIDs). Triptans are more effective when used early, before allodynia and sensitization begin. Nontriptan abortive medications include acetaminophen, aspirin, NSAIDs, caffeine, and metoclopramide, as well as dichloralphenazone alone and in combination. Dihydroergotamine (DHE) injections and dihydroergotamine and caffeine nasal spray are also options. Antiemetics include ondansetron and promethazine. Other pain medications include opioids, butalbital, and hydrocodone. Dr. Robbins uses steroids, injectable opioids, butorphanol nasal spray, and fentanyl when the usual abortives do not work. For some patients with intractable headaches, monoamine oxidase inhibitors (MAOIs), stimulants, occipital stimulators, patent foramen ovale surgery, occipital nerve blocks, and cervical injections may be helpful. Dr. Robbins objected to the use of algorithms for the treatment of headache.
"Comorbidities shape how we treat headache patients; anxiety, depression, bipolar spectrum and personality disorders, attention-deficit/hyperactivity disorder, addictions, and insomnia will all influence how we treat the headache," observed Dr. Robbins. "Medical comorbidities that affect the gastrointestinal system, irritable bowel syndrome, constipation, and diarrhea will also influence treatment choice," he added.
"For example, amitriptyline can cause weight gain, constipation, and fatigue, so we wouldn't use it in patients predisposed to these symptoms."
In addition to medical therapies, psychotherapy, biofeedback, exercise, yoga, massage, acupuncture, and other treatments may be useful. "Acceptance is very important, not resignation," advised Dr. Robbins. "However, the patient may have acceptance, but their spouse or family may not, which increases the anxiety and stress of the patient. In addition, active coping is very important compared to passive coping. We want to promote self-efficacy."
Dr. Robbins concluded, "We are not treating headaches, we are treating people and trying to enhance quality of life."
Management of Fibromyalgia
Philip Mease, MD, Chief, Division of Clinical Research, Swedish Hospital Medical Center, Seattle, Washington, described fibromyalgia as a condition characterized by heightened pain sensitivity, fatigue, sleep disturbance, and other symptoms due to dysregulation of neurophysiologic function. Fibromyalgia is not simply a condition that occurs in the developed world; it has a prevalence worldwide ranging from 0.7% (Denmark) to 10.5% (Norway). In the United States, the prevalence of fibromyalgia is 2%.
Fibromyalgia may be diagnosed by applying ACR criteria, which include a history of chronic widespread pain for at least 3 months and identification of at least 11 out of 18 tender points. The ACR diagnostic criteria are 88.4% sensitive and 81.1% specific. Fibromyalgia appears to have a multifactorial pathophysiology, which includes a strong familial predisposition, central pain amplification, psychiatric comorbid conditions, and other factors, such as immune dysregulation and the role of neurohormones such as dopamine, and growth hormone. Magnetic resonance imaging studies have provided objective evidence to show that patients with fibromyalgia have a lower threshold for pain sensitivity.
Multiple comorbid symptoms and syndromes may accompany fibromyalgia, including tension/migraine headache, affective disorders, temporomandibular joint disorder, idiopathic low back pain, irritable bowel syndrome, nondermatomal paresthesias, fatigue, memory and cognitive difficulties, and others. Tension headache is one of the most common comorbidities, occurring in over 70% of women and 50% of men with fibromyalgia.
After confirming a diagnosis, Dr. Mease recommended the identification of important symptom domains, their severity, and level of patient function. The only diagnostic instrument that has been validated for measure of function and quality of life in fibromyalgia is the Fibromyalgia Impact Questionnaire (FIQ). Patients should be evaluated for comorbid medical and psychiatric disorders, psychosocial stressors, level of fitness, and barriers to treatment. Education should be provided about fibromyalgia and treatment options should be reviewed.
Despite different modes of action, a variety of neuromodulatory agents may improve the symptoms of fibromyalgia patients. These include antidepressants, analgesics, anticonvulsants, muscle relaxants, and sedative hypnotic drugs. Only 2 drugs are FDA-approved for the specific treatment of fibromyalgia: pregabalin (Lyrica®) and duloxetine hydrochloride (Cymbalta®). However, many other medications are used off-label for the treatment of fibromyalgia.
Two pivotal phase 3 trials of the investigational drug milnacipran have been completed recently and showed favorable results for the treatment of fibromyalgia. Statistically significant durable pain relief as well as multidimensional symptom improvement lasted at least 1 year. The main adverse event was nausea (36.7%), with other adverse effects similar to those associated with duloxetine. Milnacipran has been approved in Europe and Asia for the treatment of depression.
Nonpharmacologic therapy for fibromyalgia includes aerobic exercise, cognitive-behavioral therapy, patient education, strength training, acupuncture, biofeedback, balneotherapy, and hypnotherapy. Both the patient's pain and comorbid conditions should be treated. Referral to a specialist may be necessary for complex cases.
Conclusions
The treatment of chronic pelvic pain, migraine, and fibromyalgia requires a directed history, physical examination, and laboratory evaluations to rule out other diagnoses and appreciation of multiple comorbidities that may influence the expression of symptoms and guide treatment choice. Multiple treatment modalities are available, which must be individualized for each patient.
This activity is supported by an educational grant from PriCara, Division of Ortho-McNeil-Janssen Pharmaceuticals Inc., administered by Ortho-McNeil Janssen Scientific Affairs, LLC.
Friday, December 19, 2008
Top 5 Motivation Tips for Those Who Hate to Exercise
http://www.healthy-environments.com/exercise-tips.asp
You know those people that get up before dawn to exercise and the ones that work out for hours at the gym like its their part-time job? They seem to live for exercise! Maybe you are not one of them. Even those who hate to work out may come to learn to enjoy the benefits of exercise with these 5 easy exercise tips. Just by moving more you could experience some natural allergy relief as well.
1) Set small goals. You are setting yourself up for failure if you think you are going to lose 30 lbs. next month or if you sign up for a marathon when you can't walk a mile. Take 'baby steps' for success. Make your goals more realistic, like losing 2 lbs., or walking 20 min. 3 times a week. When you see you have achieved those smaller goals you'll feel better about what you are doing.
2) Use others successes to motivate you. If you see a friend lose weight you might feel a bit envious. You might even think that losing weight is just easier for them. Instead of feeling discouraged, make your friend's success a motivation for you. "If she can do it, so can I!" It makes it seem more possible...so cheer your friend on !
3) Say Good-bye to negative self-talk. It's really easy to get down on yourself, especially at the beginning of an exercise program. You know the words: "How did I get so fat? I can never look as good as I used to." So, while working out concentrate on what your body can do. Avoid negative thoughts and say things like, " I am getting stronger every day." Studies show that your body believes what the mind keeps telling it.
4) Finish with a 'Bang'... Studies show that if you finish your workout doing things you like that are relaxing and pleasurable, you will have the tendency to come back. If you finish your work out with a series of grueling exercises that cause you pain, that is what you'll remember and you'll avoid coming back. So, finish that workout with a relaxing stretch, maybe to some fun music, and your mind will remember that good feeling. You want to keep up the exercise routine for the best health benefits so do what you can to make that happen.
5) Treat yourself. This doesn't mean to treat yourself with a double-dip ice cream cone. Set your small goals for the week...like 3 mornings a week of 30 min. exercise = a hot bubble bath or a massage. Pick something you enjoy and set your sites to having it when you achieve your goals. Your body will thank you by feeling more energetic and looking better!
For more info on how to lose fat and build muscle FAST
You know those people that get up before dawn to exercise and the ones that work out for hours at the gym like its their part-time job? They seem to live for exercise! Maybe you are not one of them. Even those who hate to work out may come to learn to enjoy the benefits of exercise with these 5 easy exercise tips. Just by moving more you could experience some natural allergy relief as well.
1) Set small goals. You are setting yourself up for failure if you think you are going to lose 30 lbs. next month or if you sign up for a marathon when you can't walk a mile. Take 'baby steps' for success. Make your goals more realistic, like losing 2 lbs., or walking 20 min. 3 times a week. When you see you have achieved those smaller goals you'll feel better about what you are doing.
2) Use others successes to motivate you. If you see a friend lose weight you might feel a bit envious. You might even think that losing weight is just easier for them. Instead of feeling discouraged, make your friend's success a motivation for you. "If she can do it, so can I!" It makes it seem more possible...so cheer your friend on !
3) Say Good-bye to negative self-talk. It's really easy to get down on yourself, especially at the beginning of an exercise program. You know the words: "How did I get so fat? I can never look as good as I used to." So, while working out concentrate on what your body can do. Avoid negative thoughts and say things like, " I am getting stronger every day." Studies show that your body believes what the mind keeps telling it.
4) Finish with a 'Bang'... Studies show that if you finish your workout doing things you like that are relaxing and pleasurable, you will have the tendency to come back. If you finish your work out with a series of grueling exercises that cause you pain, that is what you'll remember and you'll avoid coming back. So, finish that workout with a relaxing stretch, maybe to some fun music, and your mind will remember that good feeling. You want to keep up the exercise routine for the best health benefits so do what you can to make that happen.
5) Treat yourself. This doesn't mean to treat yourself with a double-dip ice cream cone. Set your small goals for the week...like 3 mornings a week of 30 min. exercise = a hot bubble bath or a massage. Pick something you enjoy and set your sites to having it when you achieve your goals. Your body will thank you by feeling more energetic and looking better!
For more info on how to lose fat and build muscle FAST
Wednesday, November 26, 2008
Brain Plasticity - how learning changes your brain
http://www.sharpbrains.com/blog/2008/02/26/brain-plasticity-how-learning-changes-your-brain/
You may have heard that the brain is plastic. As you know the brain is not made of plastic! Neuroplasticity or brain plasticity refers to the brain’s ability to CHANGE throughout life. The brain has the amazing ability to reorganize itself by forming new connections between brain cells (neurons).
In addition to genetic factors, the environment in which a person lives, as well as the actions of that person, play a role in plasticity.
Neuroplasticity occurs in the brain:
1- At the beginning of life: when the immature brain organizes itself.
2- In case of brain injury: to compensate for lost functions or maximize remaining functions.
3- Through adulthood: whenever something new is learned and memorized
Plasticity and brain injury
A surprising consequence of neuroplasticity is that the brain activity associated with a given function can move to a different location as a consequence of normal experience, brain damage or recovery.
In his book “The Brain That Changes Itself: Stories of Personal Triumph from the Frontiers of Brain Science”, Norman Doidge describes numerous examples of functional shifts.
In one of them, a surgeon in his 50s suffers a stroke. His left arm is paralyzed. During his rehabilitation, his good arm and hand are immobilized, and he is set to cleaning tables. The task is at first impossible. Then slowly the bad arm remembers how too move. He learns to write again, to play tennis again: the functions of the brain areas killed in the stroke have transferred themselves to healthy regions!
The brain compensates for damage by reorganizing and forming new connections between intact neurons. In order to reconnect, the neurons need to be stimulated through activity.
Plasticity, learning and memory
For a long time, it was believed that as we aged, the connections in the brain became fixed. Research has shown that in fact the brain never stops changing through learning. Plasticity IS the capacity of the brain to change with learning. Changes associated with learning occur mostly at the level of the connections between neurons. New connections can form and the internal structure of the existing synapses can change.
Did you know that when you become an expert in a specific domain, the areas in your brain that deal with this type of skill will grow?
For instance, London taxi drivers have a larger hippocampus (in the posterior region) than London bus drivers (Maguire, Woollett, & Spiers, 2006)…. Why is that? It is because this region of the hippocampus is specialized in acquiring and using complex spatial information in order to navigate efficiently. Taxi drivers have to navigate around London whereas bus drivers follow a limited set of routes.
Plasticity can also be observed in the brains of bilinguals (Mechelli et al., 2004). It looks like learning a second language is possible through functional changes in the brain: the left inferior parietal cortex is larger in bilingual brains than in monolingual brains.
Plastic changes also occur in musicians brains compared to non-musicians. Gaser and Schlaug (2003) compared professional musicians (who practice at least 1hour per day) to amateur musicians and non-musicians. They found that gray matter (cortex) volume was highest in professional musicians, intermediate in amateur musicians, and lowest in non-musicians in several brain areas involved in playing music: motor regions, anterior superior parietal areas and inferior temporal areas.
Finally, Draganski and colleagues (2006) recently showed that extensive learning of abstract information can also trigger some plastic changes in the brain. They imaged the brains of German medical students 3 months before their medical exam and right after the exam and compared them to brains of students who were not studying for exam at this time. Medical students’ brains showed learning-induced changes in regions of the parietal cortex as well as in the posterior hippocampus. These regions of the brains are known to be involved in memory retrieval and learning.
----------
You will find more related information on how to improve concentration and memory by checking out these resources:
- Neuroscience Interview Series: interviews with over 15 brain scientists and experts.
- Collection of brain teasers and games: attention, memory, problem-solving, visual, and more.- Brain Training Games and "Games": a 10-Question Checklist on how to evaluate programs that make brain-related claims.
You may have heard that the brain is plastic. As you know the brain is not made of plastic! Neuroplasticity or brain plasticity refers to the brain’s ability to CHANGE throughout life. The brain has the amazing ability to reorganize itself by forming new connections between brain cells (neurons).
In addition to genetic factors, the environment in which a person lives, as well as the actions of that person, play a role in plasticity.
Neuroplasticity occurs in the brain:
1- At the beginning of life: when the immature brain organizes itself.
2- In case of brain injury: to compensate for lost functions or maximize remaining functions.
3- Through adulthood: whenever something new is learned and memorized
Plasticity and brain injury
A surprising consequence of neuroplasticity is that the brain activity associated with a given function can move to a different location as a consequence of normal experience, brain damage or recovery.
In his book “The Brain That Changes Itself: Stories of Personal Triumph from the Frontiers of Brain Science”, Norman Doidge describes numerous examples of functional shifts.
In one of them, a surgeon in his 50s suffers a stroke. His left arm is paralyzed. During his rehabilitation, his good arm and hand are immobilized, and he is set to cleaning tables. The task is at first impossible. Then slowly the bad arm remembers how too move. He learns to write again, to play tennis again: the functions of the brain areas killed in the stroke have transferred themselves to healthy regions!
The brain compensates for damage by reorganizing and forming new connections between intact neurons. In order to reconnect, the neurons need to be stimulated through activity.
Plasticity, learning and memory
For a long time, it was believed that as we aged, the connections in the brain became fixed. Research has shown that in fact the brain never stops changing through learning. Plasticity IS the capacity of the brain to change with learning. Changes associated with learning occur mostly at the level of the connections between neurons. New connections can form and the internal structure of the existing synapses can change.
Did you know that when you become an expert in a specific domain, the areas in your brain that deal with this type of skill will grow?
For instance, London taxi drivers have a larger hippocampus (in the posterior region) than London bus drivers (Maguire, Woollett, & Spiers, 2006)…. Why is that? It is because this region of the hippocampus is specialized in acquiring and using complex spatial information in order to navigate efficiently. Taxi drivers have to navigate around London whereas bus drivers follow a limited set of routes.
Plasticity can also be observed in the brains of bilinguals (Mechelli et al., 2004). It looks like learning a second language is possible through functional changes in the brain: the left inferior parietal cortex is larger in bilingual brains than in monolingual brains.
Plastic changes also occur in musicians brains compared to non-musicians. Gaser and Schlaug (2003) compared professional musicians (who practice at least 1hour per day) to amateur musicians and non-musicians. They found that gray matter (cortex) volume was highest in professional musicians, intermediate in amateur musicians, and lowest in non-musicians in several brain areas involved in playing music: motor regions, anterior superior parietal areas and inferior temporal areas.
Finally, Draganski and colleagues (2006) recently showed that extensive learning of abstract information can also trigger some plastic changes in the brain. They imaged the brains of German medical students 3 months before their medical exam and right after the exam and compared them to brains of students who were not studying for exam at this time. Medical students’ brains showed learning-induced changes in regions of the parietal cortex as well as in the posterior hippocampus. These regions of the brains are known to be involved in memory retrieval and learning.
----------
You will find more related information on how to improve concentration and memory by checking out these resources:
- Neuroscience Interview Series: interviews with over 15 brain scientists and experts.
- Collection of brain teasers and games: attention, memory, problem-solving, visual, and more.- Brain Training Games and "Games": a 10-Question Checklist on how to evaluate programs that make brain-related claims.
Tuesday, November 18, 2008
Hydration tips:
Source: Backcountry.com Newsletter Articles -
Cold Sweat: Winter Dehydration - How winter conspires to dehydrate you by Chris Solomon
1. Start right. Slowly drink about 17 oz. of water more than one hour before you exercise.
2. Drink early. Studies show that people are already about 2 percent dehydrated by they time they feel thirsty.
3. Drink often. It's not rare for a hard-charging skier to perspire one quart of fluid an hour, or more. Drink 6 to 10 oz. every 15 minutes.
A general rule of thumb: Your urine should be no darker than lemonade, and ample.
Gatorade or Water?
Sports drinks may help the gut absorb fluid a modest amount faster than water alone, but water is a perfectly fine hydrator, says Dr. John Castellani, research physiologist at the U.S. Army Research Institute of Environmental Medicine's Thermal and Mountain Medicine Division. (Carry an energy bar for carbs, though.)
4. Don't stop when the lifts stop. Alcohol dessicates an already-dehydrated body. Replace sweat with water before you hit the bar or hot tub.
Cold Sweat: Winter Dehydration - How winter conspires to dehydrate you by Chris Solomon
1. Start right. Slowly drink about 17 oz. of water more than one hour before you exercise.
2. Drink early. Studies show that people are already about 2 percent dehydrated by they time they feel thirsty.
3. Drink often. It's not rare for a hard-charging skier to perspire one quart of fluid an hour, or more. Drink 6 to 10 oz. every 15 minutes.
A general rule of thumb: Your urine should be no darker than lemonade, and ample.
Gatorade or Water?
Sports drinks may help the gut absorb fluid a modest amount faster than water alone, but water is a perfectly fine hydrator, says Dr. John Castellani, research physiologist at the U.S. Army Research Institute of Environmental Medicine's Thermal and Mountain Medicine Division. (Carry an energy bar for carbs, though.)
4. Don't stop when the lifts stop. Alcohol dessicates an already-dehydrated body. Replace sweat with water before you hit the bar or hot tub.
Thursday, September 18, 2008
Treadmill Improve Stroke Recovery
(WebMD)
http://www.cbsnews.com/stories/2008/08/28/health/webmd/main4394326.shtml?source=RSSattr=HOME_4394326
Treadmill exercise may improve stroke survivors' walking ability by rewiring parts of the brain, according to a new study. The study also shows treadmill exercise may be better than stretching, the traditional exercise prescribed after a stroke, both for walking and overall fitness.
Researchers at the University of Maryland and Baltimore Veterans Affairs Medical Center compared 37 patients who performed "progressive task repetitive treadmill therapy" with 34 patients who did stretching. The patients had chronic hemiparesis, which is weakness on one side of the body, at least six months after a stroke. The patients had all completed conventional rehabilitation. The treadmill group was given the goal of three 40-minute sessions per week on the treadmill at 60 percent of their heart rate reserve. They started out slower, adding duration and intensity every two weeks. The exercise program lasted six months. The stretching group had the same number of sessions, and the length of each session was also the same. They performed a variety of traditional stretches on a raised mat table with the assistance of an instructor.
Researchers measured results in three ways: by looking at brain activity on MRIs, by measuring walking ability, and by evaluating overall fitness level.
The treadmill group performed better in all three categories. Treadmill participants increased their activity in certain parts of the brain by 72 percent on imaging tests. Brain activity changes did not occur in patients who did stretching exercise. Researchers checked brain MRIs while participants did knee-flexing exercises that mimic walking. The MRIs showed increased blood oxygenation and flow in the brain stem and cerebellum of the stroke survivors who had used the treadmill but not in those who did stretching.
Researchers say the increases in blood oxygenation and flow indicated that the cerebellum and brain stem had been "recruited" to replace some of the walking functions of the cortical brain that had been damaged by the strokes. "We saw what we call an equivalent of neuroplasticity - a change in brain activation that reflects the brain's adaptability," says Andreas Luft, MD, in a news release. Luft is one of the study's lead authors and a professor of clinical neurology and neurorehabilitation in the department of neurology at the University of Zurich, Switzerland.
The treadmill group also increased their walking speed and their fitness more than those in the stretching group. This is particularly important because stroke survivors' immobility can lead to cardiovascular disease and diabetes. In the study, published in Stroke: Journal of the American Heart Association, the authors argue that treadmill exercise should be included in long-term therapy programs for stroke survivors. "It is promising that treadmill exercise can stimulate new or underused brain circuits and improve walking in stroke survivors even after completion of conventional rehabilitation therapy," Luft says.
By Caroline WilbertReviewed by Elizabeth Klodas
http://www.cbsnews.com/stories/2008/08/28/health/webmd/main4394326.shtml?source=RSSattr=HOME_4394326
Treadmill exercise may improve stroke survivors' walking ability by rewiring parts of the brain, according to a new study. The study also shows treadmill exercise may be better than stretching, the traditional exercise prescribed after a stroke, both for walking and overall fitness.
Researchers at the University of Maryland and Baltimore Veterans Affairs Medical Center compared 37 patients who performed "progressive task repetitive treadmill therapy" with 34 patients who did stretching. The patients had chronic hemiparesis, which is weakness on one side of the body, at least six months after a stroke. The patients had all completed conventional rehabilitation. The treadmill group was given the goal of three 40-minute sessions per week on the treadmill at 60 percent of their heart rate reserve. They started out slower, adding duration and intensity every two weeks. The exercise program lasted six months. The stretching group had the same number of sessions, and the length of each session was also the same. They performed a variety of traditional stretches on a raised mat table with the assistance of an instructor.
Researchers measured results in three ways: by looking at brain activity on MRIs, by measuring walking ability, and by evaluating overall fitness level.
The treadmill group performed better in all three categories. Treadmill participants increased their activity in certain parts of the brain by 72 percent on imaging tests. Brain activity changes did not occur in patients who did stretching exercise. Researchers checked brain MRIs while participants did knee-flexing exercises that mimic walking. The MRIs showed increased blood oxygenation and flow in the brain stem and cerebellum of the stroke survivors who had used the treadmill but not in those who did stretching.
Researchers say the increases in blood oxygenation and flow indicated that the cerebellum and brain stem had been "recruited" to replace some of the walking functions of the cortical brain that had been damaged by the strokes. "We saw what we call an equivalent of neuroplasticity - a change in brain activation that reflects the brain's adaptability," says Andreas Luft, MD, in a news release. Luft is one of the study's lead authors and a professor of clinical neurology and neurorehabilitation in the department of neurology at the University of Zurich, Switzerland.
The treadmill group also increased their walking speed and their fitness more than those in the stretching group. This is particularly important because stroke survivors' immobility can lead to cardiovascular disease and diabetes. In the study, published in Stroke: Journal of the American Heart Association, the authors argue that treadmill exercise should be included in long-term therapy programs for stroke survivors. "It is promising that treadmill exercise can stimulate new or underused brain circuits and improve walking in stroke survivors even after completion of conventional rehabilitation therapy," Luft says.
By Caroline WilbertReviewed by Elizabeth Klodas
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